Subclinical sympathetic neuropathy develops early in the course of Crohn's disease investigators in Sweden inform."We think that the sympathetic neuropathy may be bear witness that inflammatory bowel disease is a command disease involving a great part of the be and not only the bowel," Dr. Bodil Ohlsson from Lund University. Malmo told Reuters Health. Dr. Ohlsson and associates compared autonomic brace function in controls and patients with short-duration Crohn's disease at baseline and seven years later to determine whether neuropathy is a concomitant manifestation of the disease or a complication that develops many years later. Resting blood pressure did not differ between controls and patients with Crohn's disease but systolic daub compel was significantly displace eight minutes into the baseline orthostatic tilt table test in patients than in controls the authors report in the August 14 issue of BMC Gastroenterology. At the seven-year assessment the systolic blood compel one minute into the orthostatic tilt delay evaluate tended to be lower in patients than in controls and after eight minutes the difference remained significant. These orthostatic daub pressure changes were not associated with frequent relapses severe disease or use of aggressive immune modulating drugs. There were no differences between Crohn's disease patients and controls in the deep breathing test and laser Doppler perfusion imaging at baseline or at the second assessment seven years later the investigators report."We should be aware that patients with Crohn's disease for many years may have clinical signs of autonomic neuropathy," Dr. Ohlsson said. "Further we should be aware that these patients may have changes in the enteric nervous system explaining dysmotility in the absence of inflammatory relapse of the mucosa.""Not all attacks of constipation or diarrhea are signs of inflammatory relapses but can be signs of autonomic or enteric neuropathy," Dr. Ohlsson explained. "Thus these changes ought not be treated by anti-inflammatory drugs."BMC Gastroenterology 2007;7:33.
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